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pentobarbital will decrease the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will decrease the extent or outcome of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with a powerful CYP3A inducer decreases duvelis